In frozen embryo transfer cycles—
Statistically Equal Pregnancy Rates Regardless of Serum Progesterone Level1
 |
Study design: Results of a retrospective chart review in 96 women who underwent a frozen embryo transfer cycle. All patients received estradiol and, starting on cycle day 15 (2 days prior to embryo transfer), either Crinone 8% (90 mg BID), Prometrium capsules used vaginally (200 mg TID), or IM progesterone (50 mg QD).
*No statistically significant difference in pregnancy rate when comparing Crinone 8% and Prometrium, Crinone 8% and IM progesterone, or Prometrium and IM progesterone.
†Serum progesterone level was significantly higher with IM progesterone versus either Crinone 8% or Prometrium. |
Prometrium is a registered trademark of Solvay Pharmaceuticals, Inc.
Reference: 1. Williams SC, Donahue J, Muasher SJ. Vaginal progesterone therapy during programmed cycles for frozen embryo transfer: an analysis of serum progesterone levels and pregnancy rates. Fertil Steril. 2000;74(suppl 1):S209. Abstract P-363.
Important Safety Information
The most common side effects of CRINONE (progesterone gel) 8% include breast enlargement, constipation, somnolence, nausea, headache, and perineal pain. CRINONE 8% is contraindicated in patients with active, or a history of, thrombophlebitis or thromboembolic disorders, patients who have known sensitivity to CRINONE 8%, missed abortion, undiagnosed vaginal bleeding, liver dysfunction or disease, and known or suspected malignancy of the breast or genital organs. Should any of the earliest manifestations of thrombotic disorders occur, the drug should be discontinued immediately. No adequate evidence is available to show that progesterone and progestins are effective in preventing miscarriage in women with a history of recurrent spontaneous pregnancy losses. The pretreatment physical exam should include special reference to breast and pelvic organs as well as a Papanicolaou smear. Nonfunctional causes of breakthrough bleeding should be considered, and for undiagnosed vaginal bleeding, diagnostic measures should be undertaken. Special care should be taken with patients who have conditions that may be influenced by fluid retention, those who have a history of psychic depression, and those with diabetes.