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In frozen embryo transfer cycles—

 

Crinone 8% Versus IM: Statistically Equal Pregnancy Rates Regardless of Serum Progesterone Level1

 

Study design: Results of a retrospective chart review in 96 women who underwent a frozen embryo transfer cycle. All patients received estradiol and, starting on cycle day 15 (2 days prior to embryo transfer), either Crinone 8% (90 mg BID), Prometrium capsules used vaginally (200 mg TID), or IM progesterone (50 mg QD).

 

*No statistically significant difference in pregnancy rate when comparing Crinone 8% and Prometrium, Crinone 8% and IM progesterone, or Prometrium and IM progesterone.

 

†Serum progesterone level was significantly higher with IM progesterone versus either Crinone 8% or Prometrium.

 

Prometrium is a registered trademark of Solvay Pharmaceuticals, Inc.

 

Reference: 1. Williams SC, Donahue J, Muasher SJ. Vaginal progesterone therapy during programmed cycles for frozen embryo transfer: an analysis of serum progesterone levels and pregnancy rates. Fertil Steril. 2000;74(suppl 1):S209. Abstract P-363.