In IVF and donor egg cycles—
Significantly Higher Pregnancy Outcomes With Patient-preferred Administration1
Crinone 8% is more effective than historical controls
As reported by 16 centers in this trial, Crinone 8% demonstrated significantly higher clinical pregnancy rates in women undergoing IVF and donor egg cycles when compared with last data reported by SART from the same centers.
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Preferred by patients1
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| Study design: A multicenter study of 1287 women receiving Crinone 8% for IVF, donor egg, or IUI cycles. Treatment was initiated as per each center’s routine. Results were compared with historical controls. Patient acceptance was assessed by questionnaires completed by patients at the end of treatment. |
Reference: 1. Levine H. Luteal support from the vaginal progesterone (P) gel Crinone 8%: preliminary results of multicenter trial show higher pregnancy rates than historical controls. J Soc Gynecol Investig. 2000;7(suppl). Abstract 571.
Important Safety Information
The most common side effects of CRINONE (progesterone gel) 8% include breast enlargement, constipation, somnolence, nausea, headache, and perineal pain. CRINONE 8% is contraindicated in patients with active, or a history of, thrombophlebitis or thromboembolic disorders, patients who have known sensitivity to CRINONE 8%, missed abortion, undiagnosed vaginal bleeding, liver dysfunction or disease, and known or suspected malignancy of the breast or genital organs. Should any of the earliest manifestations of thrombotic disorders occur, the drug should be discontinued immediately. No adequate evidence is available to show that progesterone and progestins are effective in preventing miscarriage in women with a history of recurrent spontaneous pregnancy losses. The pretreatment physical exam should include special reference to breast and pelvic organs as well as a Papanicolaou smear. Nonfunctional causes of breakthrough bleeding should be considered, and for undiagnosed vaginal bleeding, diagnostic measures should be undertaken. Special care should be taken with patients who have conditions that may be influenced by fluid retention, those who have a history of psychic depression, and those with diabetes.