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In IVF-ET/ICSI cycles—

 

Comparable Clinical Pregnancy Rates Versus IM Progesterone With Less Discomfort1

 

Study design: Results of a prospective, randomized trial of 99 women receiving luteal phase support for an IVF-ET/ICSI cycle. Patients were randomized to receive Crinone 8% (90 mg QD) or IM progesterone (50 mg QD), starting on the day of oocyte retrieval.
  • Serum progesterone levels were significantly higher in the patients treated with IM progesterone versus Crinone 8%

Crinone 8% provides a more comfortable administration

 

“[O]ur data favor the vaginal route over the intramuscular route, both in absolute terms (significantly more patients experienced no discomfort when using Crinone), and in terms of the intensity of discomforts that were reported.”

 

Reference: 1. Anserini P, Costa M, Remorgida V, Sarli R, Guglielminetti E, Ragni N. Luteal phase support in assisted reproductive cycles using either vaginal (Crinone 8) or intramuscular (Prontogest) progesterone: results of a prospective, randomized study [in Italian]. Minerva Ginecol. 2001;53:297–301.