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In IVF-ET cycles—

 

Comparable Pregnancy Rates Versus IM Progesterone1

 

Interim results from the largest prospective, randomized, controlled trial of Crinone 8% and IM progesterone

 

Study design: Results of a prospective, randomized trial of 215 women younger than 40 years receiving progesterone for an IVF-ET cycle. Patients were randomized to receive Crinone 8% (90 mg QD, starting 48 hours after oocyte retrieval) or IM progesterone (50 mg QD, starting 24 hours after oocyte retrieval). All patients with a positive pregnancy test in both groups received Crinone 8% until 10 weeks’ gestation.

 

No significant difference in ongoing pregnancy or miscarriage rates despite greater bleeding with Crinone 8%

  • Early spontaneous abortion: 28.6% (Crinone 8%) versus 26.1% (IM progesterone), P=NS
  • Vaginal bleeding between oocyte retrieval and pregnancy test: 42% (Crinone 8%) versus 27% (IM progesterone), P=.02

Reference: 1. Yanushpolsky E, Hurwitz S, Greenberg L, Racowsky C, Hornstein MD. Comparison of Crinone 8% intravaginal gel and intramuscular progesterone supplementation for in vitro fertilization/embryo transfer in women under age 40: interim analysis of a prospective randomized trial. Fertil Steril. 2008;89:485–487.