In IVF-ET cycles—

Effective, Once-daily Luteal Support Confirmed

in 12 Studies

Click on the Lead Author’s name for more information about each study.

Lead Author	Comparator Forms of Progesterone	Comparable Pregnancy Outcomes
Yanushpolsky E1 Fertil Steril, 2008	Crinone 8% (90 mg QD) IM (50 mg QD)
Saucedo LLE2 ESHRE,* 2003	Crinone 8% (90 mg QD) IM (50 mg QD)
Anserini P3 Minerva Ginecol, 2001	Crinone 8% (90 mg QD) IM (50 mg QD)
Coutifaris C4 Fertil Steril, 2000	Crinone 8% (90 mg QD) IM (50 mg QD)
Schoolcraft WB5 Hum Reprod, 2000	Crinone 8% (90 mg QD) IM (50 mg QD)
Chantilis SJ6 Fertil Steril, 1999	Crinone 8% (90 mg QD) IM (50 mg QD)
Saucedo LLE7 Fertil Steril, 2000	Crinone 8% (90 mg QD) IM (50 mg QD) Oral (400 mg QD)	†
Alper MM8 ESHRE, 2000	Crinone 8% (90 mg QD) IM (50 mg QD) Vaginal suppositories (100 mg QD)
Simunic V9 Fertil Steril, 2007	Crinone 8% (90 mg QD) Vaginally administered capsules (200 mg TID)
Geber S10 Reprod BioMed Online, 2007	Crinone 8% (90 mg QD) Vaginally administered capsules (200 mg TID)
Ludwig M11 Eur J Obstet Gynecol Reprod Biol, 2002	Crinone 8% (90 mg QD) Vaginally administered capsules (200 mg TID)
Doody K12 Fertil Steril, 2007	Crinone 8% (90 mg QD) Endometrin® (100 mg BID or TID)

References: 1. Yanushpolsky E, Hurwitz S, Greenberg L, Racowsky C, Hornstein MD. Comparison of Crinone 8% intravaginal gel and intramuscular progesterone supplementation for in vitro fertilization/embryo transfer in women under age 40: interim analysis of a prospective randomized trial. Fertil Steril. 2008;89:485–487. 2. Saucedo LLE, Batiza V, Arenas L, et al. Progesterone for luteal support: randomized, prospective trial comparing vaginal and i.m. administration. Paper presented at the 19th Annual Meeting of the European Society for Human Reproduction & Embryology; July 2003; Madrid, Spain. Abstract P-383. 3. Anserini P, Costa M, Remorgida V, Sarli R, Guglielminetti E, Ragni N. Luteal phase support in assisted reproductive cycles using either vaginal (Crinone 8) or intramuscular (Prontogest) progesterone: results of a prospective, randomized study [in Italian]. Minerva Ginecol. 2001;53:297–301. 4. Coutifaris C, Patrizio P, Schafer D, Bunso S, Bucci J, Barnhart K. Is the use of Crinone for support of the luteal phase detrimental to pregnancy outcome after transfer of non-cryopreserved embryos in good prognosis patients? A preliminary report. Fertil Steril. 2000;74(suppl 1):S205. Abstract P-350. 5. Schoolcraft WB, Hesla JS, Gee MJ. Experience with progesterone gel for luteal support in a highly successful IVF programme. Hum Reprod. 2000;15:1284–1288. 6. Chantilis SJ, Zeitoun KM, Patel SI, et al. Use of Crinone vaginal progesterone gel for luteal support in in vitro fertilization cycles. Fertil Steril. 1999;72:823–829. 7. Saucedo LLE, Galache VP, Hernández AS, Santos HR, Arenas ML, Patrizio P. Randomized trial of three different forms of progesterone supplementation in ART: preliminary results. Fertil Steril. 2000;74(suppl 1):S150. Abstract P-175. 8. Alper MM, Penzias AS. Crinone® offers excellent implantation rates in patients undergoing IVF. Paper presented at the 16th Annual Meeting of the European Society for Human Reproduction & Embryology; June 2000; Bologna, Italy. Abstract P-059. 9. Simunic V, Tomic V, Tomic J, Nizic D. Comparative study of the efficacy and tolerability of two vaginal progesterone formulations, Crinone 8% gel and Utrogestan capsules, used for luteal support. Fertil Steril. 2007;87:83–87. 10. Geber S, Moreira AC, de Paula SO, Sampaio M. Comparison between two forms of vaginally administered progesterone for luteal phase support in assisted reproduction cycles. Reprod BioMed Online. 2007;14:155–158. Available at: rbmonline.com/Article/2551. 11. Ludwig M, Schwartz P, Babahan B, et al. Luteal phase support using either Crinone® 8% or Utrogest®: results of a prospective, randomized study. Eur J Obstet Gynecol Reprod Biol. 2002;103:48–52. 12. Doody K, Shamma N, Paulson R, Bayer S, Blake E, Yankov V. Endometrin® for luteal phase support in a randomized, controlled, open-label, prospective IVF clinical trial using a combination of Menopur® and Bravelle®. Fertil Steril. 2007;87(Suppl 2):S24. Abstract P-34.