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In donor egg cycles—

 

Pregnancy Outcomes Comparable to IM Progesterone1

 

Study design: Results of a prospective, randomized trial in 72 women receiving progesterone for a donor egg cycle. All patients received estradiol and were randomized to receive Crinone 8% (90 mg BID) or IM progesterone (100 mg QD) in a 7:3 ratio, respectively. Crinone 8% was administered from the evening of cycle day 14 until negative pregnancy test for 2 weeks or for a total of 10 weeks in case of pregnancy; IM progesterone was administered from the evening of cycle day 15 until negative pregnancy test or for a total of 10 weeks in case of pregnancy (with dosage reduced to 50 mg QD in the 8th week).

 

  • Comparable implantation rates for Crinone 8% and IM progesterone
    • 23% vs 18% (P=NS)
  • Comparable pregnancy rates despite lower serum progesterone levels for Crinone 8% versus IM progesterone
  • In-phase endometrial biopsies

 

Reference: 1. Gibbons WE, Toner JP, Hamacher P, Kolm P. Experience with a novel vaginal progesterone preparation in a donor oocyte program. Fertil Steril. 1998;69:96–101.