Crinone 8% Bioadhesive Gel Delivers Higher Uterine Levels Than IM Progesterone
- Clinical studies show comparable pregnancy rates despite differences in serum progesterone levels1–3
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| Study design: Results of a randomized, open-label study in 14 postmenopausal women who were undergoing hysterectomy. Patients were equally randomized to receive 3 doses of Crinone 8% (90 mg) or IM progesterone (50 mg) prior to surgery. Samples of the endometrium were obtained following hysterectomy and blood samples were taken prior to and during surgery. |
- Serum progesterone levels do not accurately reflect levels in the endometrium5
Accurate, unique delivery system
- Vaginal applicator allows direct delivery of prescribed dose in a single, daily application
- Bioadhesive gel provides sustained, controlled release for dependable delivery6
References: 1. Williams SC, Donahue J, Muasher SJ. Vaginal progesterone therapy during programmed cycles for frozen embryo transfer: an analysis of serum progesterone levels and pregnancy rates. Fertil Steril. 2000;74(suppl 1):S209. Abstract P-363. 2. Anserini P, Costa M, Remorgida V, Sarli R, Guglielminetti E, Ragni N. Luteal phase support in assisted reproductive cycles using either vaginal (Crinone 8) or intramuscular (Prontogest) progesterone: results of a prospective, randomized study [in Italian]. Minerva Ginecol. 2001;53:297–301. 3. Chantilis SJ, Zeitoun KM, Patel SI, et al. Use of Crinone vaginal progesterone gel for luteal support in in vitro fertilization cycles. Fertil Steril. 1999;72:823–829. 4. Cicinelli E, De Ziegler D, Bulletti C, Matteo MG, Schonauer LM, Galantino P. Direct transport of progesterone from vagina to uterus. Obstet Gynecol. 2000;95:403–406. 5. Gibbons WE, Toner JP, Hamacher P, Kolm P. Experience with a novel vaginal progesterone preparation in a donor oocyte program. Fertil Steril. 1998;69:96–101.