Significantly Greater Patient Satisfaction Versus IM Progesterone¹

Study design: Results of a prospective, randomized trial of 215 women younger than 40 years receiving progesterone for an IVF-ET cycle. Patients were randomized to receive Crinone 8% (90 mg QD, starting 48 hours after oocyte retrieval) or IM progesterone (50 mg QD, starting 24 hours after oocyte retrieval). All patients with a positive pregnancy test in both groups received Crinone 8% until 10 weeks’ gestation. At the end of each IVF-ET cycle, patients rated their satisfaction with the mode of progesterone administration on a scale of 1–5, with 5 indicating most satisfaction.

Reference: 1. Yanushpolsky E, Hurwitz S, Greenberg L, Racowsky C, Hornstein MD. Comparison of Crinone 8% intravaginal gel and intramuscular progesterone supplementation for in vitro fertilization/embryo transfer in women under age 40: interim analysis of a prospective randomized trial. Fertil Steril. 2008;89:485–487.