Progesterone Support with Crinone 8%

Why do women need progesterone supplementation?

Progesterone is an important hormone for pregnancy. It helps thicken the lining of the uterus (called the endometrium) for implantation of a fertilized egg. Progesterone also helps sustain pregnancy after implantation. (See Progesterone’s Role in Pregnancy for more information.)

Some women may experience a progesterone deficiency/inadequacy that makes it more difficult for them to become pregnant or to maintain pregnancy.

A progesterone deficiency/inadequacy can be caused by 1 of 2 factors:

• The ovaries produce little to no progesterone
• The endometrium is not responding to normal levels of progesterone

Important Safety Information

The most common side effects of CRINONE (progesterone gel) 8% include breast enlargement, constipation, drowsiness, nausea, headache, and pain in the pubic area. You should not use CRINONE 8% if you have any disorders involving blockage of your blood vessels, or a history of these disorders, miscarriages, vaginal bleeding that hasn’t been diagnosed, liver problems or disease, or known or possible cancer of the breast or genital organs. You should discontinue use of CRINONE 8% if any symptoms occur that signal a blockage of your blood vessels. There is no adequate evidence that CRINONE 8% will work in preventing miscarriage. Your doctor should examine your breasts and pelvic organs, as well as perform a Pap smear prior to prescribing CRINONE 8%. If you have vaginal bleeding during treatment with CRINONE 8%, your doctor should look for the cause. If you have conditions that cause fluid retention, a history or depression, or diabetes, your doctor should provide special attention to your care while you are using CRINONE 8%.